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In July 2009, the US Drug Enforcement Agency (DEA) listed JWH-018 powder on its Drugs and Chemicals of Concern list. In addition to reported seizures of Spice in Ohio and Florida, several states have passed legislative action restricting the sale or possession of JWH-018 powder including Alabama, Arkansas, Georgia, Kansas, Kentucky, North Dakota, and Tennessee.
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There are Various physical and psychological adverse effects have been reported from JWH-018 powder use. And One study reported psychotic relapses and anxiety symptoms in well-treated patients with mental illness following JWH-018 inhalation. Also, due to concerns about the potential of JWH-018 drug and other synthetic cannabinoids to cause psychosis in vulnerable individuals, it has been recommended that people with risk factors for psychotic illnesses (like a past or family history of psychosis) not use these substances.
